Preventing estrogen dominance

Where do you start if you have discovered estrogen dominance?

Estrogen dominance is a condition in which a woman can have a deficiency, normal level, or excess estrogen level. But at the same time, she has little or no progesterone to balance its effect on the body. Even a woman with a low estrogen level will have estrogen dominance symptoms if she doesn’t have enough progesterone. Progesterone insufficiency and poor estrogen metabolite excretion can contribute to the development of estrogen dominance.

The estrogen dominance syndrome will often occur against a decrease in progesterone, with anovulatory cycles, chronic stress, frequent time zone changes, malnutrition, and secondarily due to the failure to excrete estrogen metabolites.

After all, progesterone also protects against harmful metabolites. Therefore, women with the same detox genetics will not always develop pathology; it all depends on the progesterone level.

Progesterone, in turn, depends on estrogens since, without them, ovulation is impossible, and the corpus luteum is not formed. Without ovulation (for example, when taking Birth Control pills, in the case of amenorrhea, or with PCOS), a woman lives a long time without progesterone; thus, the risks of neoplasms and oncopathology in this situation will be higher.

When accumulated, estrogen metabolites begin to pose a danger to the human body.

Therefore, the prevention and treatment of estrogen dominance involve normalizing detoxification phases. To do this, you must improve bile flow, work with the intestines, get tested for estrogen metabolites, and be aware of your methylation genetics (especially COMT rs 4680).

Why it’s crucial to understand how the gastrointestinal tract interacts with estrogen dominance.

  • It is through the digestive tract that estrogen metabolites are neutralized and excreted.
  • It is on hormones that counteract estrogen and are in short supply against the background of estrogen dominance that the normal function of the gastrointestinal tract depends.

All hormones, including estrogen, have one precursor: cholesterol. That is, they are of a lipid nature, and fat metabolism is critical for their normal function since they will start and complete their cycle from it: heading to the liver and leaving the body along with bile. Failure of the liver detoxification phases and substrate deficiency can make it impossible to treat and prevent estrogen dominance.

Dominance can be absolute or relative.

Absolute dominance occurs when more estrogen is synthesized at the same time progesterone is normal. Relative dominance occurs when the level of estrogen is normal but the level of progesterone is low, causing a loss of equilibrium and the balancing effect of progesterone. Or there is an excess accumulation of metabolites with normal or low levels of good estrogens. The tactics in these cases will be different.

In any case, the solution to the problem of estrogen dominance is complex and requires a whole-body approach to correct the entire condition carefully.


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